Sickle Cell Disease and Anesthesia / by Muhammad Amir Ayub

After reading such a super long article (broken up into days), the inevitable conclusion was this:

Almost a half-century after anesthetic attention was first directed to this challenging disease, the fundamental of management remains meticulous observation and vigilance of the basic principles of safe anesthesia

Typical of most things in anesthesia and critical care (the literature on mortality improvement post ARDS suggests the same).